
Basic concepts and clinical challenges
in SLE and ANCA-associated vasculitis
Overview
Organising committee:
- Leiden University Medical Center (LUMC): Cees van Kooten, Onno Teng, Argho Ray, Tineke Kraaij, Arnelle Kallan, Marianne Lobbezoo
- Karolinska University: Sigrid Lundberg, Ioannis Parodis
Date: September 4th – 6th 2025 (Register before July 15th)
Location: Oud-Poelgeest, Poelgeesterweg 1, Oegstgeest
Faculty (alphabetical): Edwin Bredewold, Emilie Dronkers, Tom Huizinga, Jesper Kers, Cees van Kooten, Tineke Kraaij, Sigrid Lundberg, Thijs van Mens, Ly Nguyen, Marieke Overbeek, Judith van Paassen, Ioannis Parodis, Argho Ray, Onno Teng, Merlijn Wind
Introduction
We invite you to join us this summer in Leiden for an immersive experience for cutting-edge learning on the management of the severe, systemic manifestation of systemic autoimmune diseases.
This program is a collaboration between Leiden University Medical Center and the Karolinska Institute, two leading institutions in medical research and education, united by a shared commitment to advancing healthcare for systemic autoimmune diseases through collaboration and multidisciplinarity. Both institutes have a common vision that bringing together internists, nephrologists, rheumatologists, pulmonologist and many other specialists is the best way to provide top-academic care for patients with systemic autoimmune diseases.
The severe forms of systemic autoimmune diseases have specific challenges to the treating physician including knowledge on the basic immunological concepts, clinical tools to address acute manifestations and skills to optimally perform as a multidisciplinary team. The LeiKa summer school will focus at teaching the daily clinical practice of severe systemic autoimmune diseases with a special emphasis on kidney involvement. The goal is to bring current insights into the immunological background, clinical features and novel therapeutic options of systemic autoimmune diseases to young specialist (in training).
The LeiKa Summer School aims to equip physicians with knowledge, skills and a network to provide optimal care for this interesting and complex patient population. This summer school offers young specialists an unparalleled opportunity to expand their knowledge and network with international peers and experts.
Goals:
- Optimizing care for patients with systemic autoimmune disease, notably acute and severe presentations.
- Optimizing knowledge on basic immunology underpinning autoimmunity
- To raise awareness of the need for multi-disciplinary care, collaboration and consultation by medical specialists
Target audience:
- A broad scope of medical young professionals, including residents and specialists, with specific interest in autoimmunity from the fields within Internal Medicine, Rheumatology, Pulmonology, Dermatology, ENT medicine, Ophthalmology, Cardiology, Intensive Care.
- Aim is to recruit 20-25 international participants in the first edition of the summer school.
Our partnership with Karolinska Institute is built on a foundation of excellence in research and clinical innovation.
Both Leiden University and Karolinska have been at the forefront of medical research for centuries, sharing a commitment to pushing the boundaries of autoimmunity research, innovation and clinical care. Together, we are able to provide an environment where young specialists are challenged to learn, understand and take action to improve the care for systemic autoimmune diseases through lectures, workshops, and interactive sessions led by world-renowned experts from both institutions.
Join the Leiden – Karolinska Summer School 2025!
Program (Overview)
The LeiKa summer school will deal with all aspects of systemic autoimmune diseases, with special emphasis on the most severe manifestations and their complex and challenging care. The kidneys are often involved in systemic autoimmune diseases and kidney biopsies routinely include immunofluorescence and electron microscopy and therefore provide an ideal illustration of the underlying pathophysiology of systemic autoimmune diseases. Disease activity in major organs such as the heart, brain, lungs or kidneys often prompts more intensive therapy but also more personalized treatment decisions. The latter can profit from pathophysiology-based treatment strategies and therefore the course will thoroughly review the latest insights into the immunological background, clinical features and novel therapeutic options of systemic autoimmune diseases. Lastly, empowering multidisciplinary teams of physicians is crucial to optimize treatment of patients with systemic autoimmune disease and will be part of the course.
General aspects of the programme:
- “Mastermind challenge”; during the summer school, participants will be given an assignment to work on in groups. Groups of 4-5 participants will be made. Each group receives a unique patient case on day 1 which they will work on throughout the whole course, ending with a presentation of their findings on the last day of the summer school.
- Daily case presentations by faculty.
- Daily presentation on novel therapeutics.
- Daily basic immunology and pathology sessions.
- Social program on Friday (late afternoon/ evening).
Activities
Alongside our academic sessions, we’ve arranged a series of social activities to provide networking opportunities.
Welcome Dinner: The first day will end with a welcome dinner, where you’ll have the chance to meet fellow participants and faculty in an informal setting.
Boat Tour: Discover the beauty of Leiden from the water on a scenic boat tour of the city’s historic canals, where you’ll get a unique perspective on its 16th-century architecture and vibrant university life.
Whether you’re hoping to advance your career, gain insights into severe, autoimmune manifestations or simply meet like-minded peers in a beautiful setting, the Leiden-Karolinska Summer School promises an enriching experience.

Location
Nestled in the scenic landscape just outside Leiden, Landgoed Poelgeest offers a truly unique and inspiring venue for our program. This historic venue creates the perfect setting for thoughtful discussion and connection with colleagues. The atmosphere will not only enrich your academic experience but also allow you to recharge and reflect.
Costs
To accommodate a variety of preferences and needs, we offer two program tiers for participants: with or without an overnight stay at the location. Accreditation from relevant organisations is pending.
Full residency (€500,00/€650,00)
Includes 2/3 nights of accommodation at the Poelgeest congress venue, immersing you fully in the summer school experience. Staying on-site means you’ll enjoy convenient access to all sessions, lunches, 3-course dinners, and evening events, along with the opportunity to forge deeper connections with fellow attendees and faculty in the inspiring atmosphere of this historic domain.
Day Program (€200,00)
This option allows local participants or those preferring off-site arrangements to attend all educational sessions and social activities without overnight accommodations. You’ll still enjoy daily meals, including lunch, 3-course dinner and evening events, giving you access to the same rich program and networking opportunities.
Fifth- and sixth-year residents receive a 50% discount.
Are you joining the LeiKa Autoimmunity Summer School 2025?
Programme (Detailed)
Day 1: ANCA-associated Vasculitis (Moderated by Onno Teng)
| Time | Title | Teacher |
| 9:30 | Introduction | Onno Teng |
| Faculty & history of Leiden and Karolinska | ||
| Brief introduction of staff and participants | ||
| Formation of teams for “mastermind challenge” | ||
| 10:15 | Introduction to ANCA- associated vasculitis: What is severe? Patient cases & differential diagnosis | Sigrid Lundberg |
| 11:00 | Coffee/tea break | |
| 11:15 | The storm within ANCA-associated vasculitis Classic immunological concepts & novel insights | Cees van Kooten |
| 12:00 | Beyond the surface The histopathology of ANCA-associated vasculitis | Jesper Kers |
| 12:45 | Lunch break | |
| 14:00 | At the Edge: ANCA vasculitis turning vicious | Argho Ray |
| Threatening the Airway (e.g. subglottic stenosis/ ENT involvement) | Emilie Donkers | |
| Constricting the Airway (Pulmonary eGPA) | Marieke Overbeek | |
| 15:00 | Short break | |
| 15:30 | The LeiKa Mastermind challenge (group assignment) | Argho Ray (with all faculty) |
| 16:00 | Turning the tide in ANCA-associated vasculitis | |
| Standard-of-care and novel therapeutics for AAV | Onno Teng | |
| Role and place for plasmapheresis in severe AAV | Edwin Bredewold | |
| 17:00 | Mastermind challenge by groups | |
| 18:30 | Welcome Dinner at the venue | |
Day 2: Lupus (Moderated by Onno Teng)
| Time | Title | Teacher |
| 9:00 | Introduction to SLE and Lupus Nephritis: what is severe? Patient cases & differential diagnosis | Onno Teng |
| 9:30 | Beyond the usual: Life-threatening manifestations of SLE | |
| If the heart fails (cardiac failure by cardiomyositis or valve insufficiency) | Edwin Bredewold | |
| If the bloodflow fails (catastrophical APS, TMA) | Thijs van Mens | |
| 10:30 | Coffee/tea break | |
| 11:00 | The complex immunological network of SLE | Cees van Kooten |
| Classical concepts and novel insights | ||
| 11:45 | Beyond the surface The histopathology of SLE and LN | Jesper Kers |
| 12:30 | Lunch break | |
| 13:30 | Beyond the usual: Life-threatening manifestations of SLE | |
| If the brain fails | Tom Huizinga | |
| Severe skin manifestations | Ly Nguyen | |
| Pregnancy and SLE / autoimmune disease | Merlijn Wind | |
| 15:00 | Mastermind challenge (group assignment) | Argho Ray (with all faculty) |
| 16:00 | Coffee/tea/soda break | |
| 16:30 | From crisis to control in severe SLE/LN Standard-of-care and novel therapeutics for SLE & LN | Onno Teng/Tineke Kraaij |
| 17:30 | Surprise dinner (not at the event location) | |
| 20:00 | Dinner end | |
Day 3: Mastermind Challenge (Moderated by Argho Ray)
| Time | Title | Teacher |
| 9:15 | Introduction | Argho Ray |
| 9:30 | Presentation group 1 | |
| 10:00 | Presentation group 2 | |
| 10:30 | Presentation group 3 | |
| 11:00 | Coffee/tea break | |
| 11:15 | Closing remarks | Onno Teng |
| 11:30 | Lunch and goodbye |
Accreditation from relevant organisations is pending.


